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. 2023 Feb 3;24(3):3047. doi: 10.3390/ijms24033047

Figure 2.

Figure 2

CASC19−related ceRNA networks were constructed on the basis of mRNAs screen: (A) CASC19−related ceRNA networks of 6 common upregulated genes (CBX5, CTSD, FKBP5, FKBP10, DHTKD1, and HSP90B1) based on the intersection of RNA−seq and TMT assays; (B) the heatmap of DEGs between tumor samples of NPC radioresistant patients before and after radiotherapy (n = 3); (C) Venny chart of the intersection of the common genes among the upregulated mRNAs regulated by lncRNAs-miRNAs in CNE2R cells (RNA−seq assay), the upregulated genes in CNE2R cells compared with CNE2 cells (TMT assay), and the upregulated genes in the patients post-radiotherapy compared with pre-radiotherapy (clinic gene chip assay). The intersection only contains one gene FKBP5; (D) the expressions of FKBP5 in the tumor tissues of NPC and its adjacent normal tissues (data from GEO databases of GSE12452 and GSE13597); (E) the expressions of FKBP5 in the head and neck squamous cell carcinoma (HNSC) and its adjacent normal tissues (data from GEPIA).