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Schematic model of the pathways regulated the radioresistance of NPC cells. CASC19, as a competing endogenous RNA, bound to miR-340-3p via the lncRNA sponging mechanism and abolished the suppression of FKBP5 expression caused by miR-340-3p. FKBP5 may bind with BECN1 or regulate AKT/FOXO3 pathway, resulting in an increase in autophagy, thereby enhancing the radioresistance of NPC. The signaling pathways in the dashed box are derived from studies in the literature.
