Table 1.
Demographic characteristics and ocular surface parameters of hypochlorous acid and control groups at baseline.
| Parameters | Mean ± SD | p Value | |
|---|---|---|---|
| HOCL | Control | ||
| Participants | 35 | 32 | |
| Male, n (%) a | 12 (34.3) | 13 (40.6) | 0.592 |
| Age, year b | 41.3 ± 15.9 | 41.1 ± 13.6 | 0.959 |
| Primary outcomes | |||
| OSDI b | 35.6 ± 19.3 | 31.8 ± 15.3 | 0.375 |
| Lid margin redness c | 1.5 ± 0.6 | 1.7 ± 0.5 | 0.053 |
| Lid margin abnormality c | 1.3 ± 0.5 | 1.3 ± 0.4 | 0.894 |
| Meibum expressibility c | 2.3 ± 0.6 | 1.8 ± 0.7 | 0.004 |
| Meibum quality c | 2.0 ± 0.3 | 1.9 ± 0.4 | 0.504 |
| NIBUT-1st, s c | 9.2 ± 4.9 | 7.6 ± 4.9 | 0.160 |
| NIBUT-avg, s c | 11.6 ± 4.3 | 10.7 ± 4.2 | 0.309 |
| Secondary outcome | |||
| Conjunctiva redness c | 1.3 ± 0.6 | 1.4 ± 0.4 | 0.388 |
| CFS score c | 0.5 ± 1.0 | 0.2 ± 0.5 | 0.490 |
| TMH, mm c | 0.3 ± 0.1 | 0.2 ± 0.1 | 0.744 |
| Meibography score c | |||
| Upper lid | 1.6 ± 0.9 | 1.8 ± 0.7 | 0.365 |
| Lower lid | 1.6 ± 0.8 | 1.4 ± 0.7 | 0.353 |
| Total | 3.2 ± 1.5 | 3.2 ± 1.2 | 0.979 |
Abbreviations: HOCL, hypochlorous acid; SD, standard deviation; OSDI, ocular surface disease index; NIBUT-1st, the first time of noninvasive breakup time; NIBUT-avg, the mean time of noninvasive breakup time; CFS, corneal fluorescein staining; TMH, tear meniscus height. a p values based on χ2 and b p values based on t test. c p values based on Wilcoxon rank sum tests. p values marked in bold indicate significant.