Table 2.
Cox regression analysis for predictors of lung function decline at any time.
| Variable | Wald Chi-Square | HR | HR 95% CI | OR * | p ** |
|---|---|---|---|---|---|
| Age, y | 1.132 | 1.010 | 0.991–1.030 | 1.024 | 0.287 |
| Gender (ref. M) | 4.454 | 1.660 | 1.037–2.657 | 3.210 | 0.035 |
| BMI, kg/m2 | 5.279 | 1.050 | 1.007–1.095 | 1.119 | 0.022 |
| KL-6 (U/mL) | 5.687 | 1.000 | 1.000–1.000 | 1.000 | 0.017 |
| FVC, % pred | 0.321 | 0.995 | 0.979–1.012 | 0.989 | 0.571 |
| DLco, % pred | 0.168 | 0.997 | 0.982–1.012 | 0.993 | 0.682 |
| Underlying ILD (ref. NSIP) | 4.739 | 0.616 | 0.000–0.953 | 0.328 | 0.029 |
* ORs were calculated as exponential of regression coefficient values derived from logistic regression (event = progression) and are shown for completeness. ** refers to HR calculation through Cox regression analysis. Abbreviations: BMI = body mass index; FVC = forced vital capacity; DLco = diffusing capacity of the lung for carbon monoxide; GAP = gender, age, physiology; HR = hazard ratio, ILD = interstitial lung disease; IQR = interquartile range; n = number; KL-6 = Krebs von den Lungen-6; NSIP = nonspecific interstitial pneumonia; OR = odds ratio; y = years.