Table A1.
Comparison of statistical performance of baseline serum KL-6 strata alone versus GK scores as predictors of disease progression at any time.
| Variable | Wald Chi-Square | HR * | HR 95% CI | p |
|---|---|---|---|---|
| Serum KL-6 (ref. > 750–1300 U/mL) | 2.521 | 1.670 | 0.887–3.146 | 0.112 |
| Serum KL-6 (ref. > 1300–2000 U/mL) | 7.600 | 2.413 | 1.290–4.513 | 0.006 |
| Serum KL-6 (ref. > 2000 U/mL) | 10.648 | 2.924 | 1.535–5.571 | 0.001 |
| GK = 1 | 0.938 | 1.633 | 0.605–4.404 | 0.333 |
| GK = 2 | 4.601 | 2.814 | 1.093–7.242 | 0.032 |
| GK = 3 | 8.109 | 3.972 | 1.537–10.265 | 0.004 |
| GK = 4 | 9.788 | 4.829 | 1.801–12.952 | 0.002 |
All serum KL-6 strata were compared to stratum ≤750 U/mL. * HRs were obtained by Cox regression. Abbreviations: G = gender; HR = hazard ratio; K = KL-6; KL-6 = Krebs von den Lungen-6.