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. 2023 Feb 3;24(3):3050. doi: 10.3390/ijms24033050

Table 1.

List of differentially expressed circular RNAs and its target miRNAs in five major mortality cancers in the previous 5 years.

Cancer Type CircRNA Symbol
/CircBase ID		 Oncogenic
/Tumor-Suppressive		 MicroRNA Target Gene Cancer Related Biological/Regulatory Process Ref.
Lung
cancer		 Circ_0000284 oncogenic miR-377-3p PD-L1 - [47]
Circ_0000376 oncogenic miR-1182 NOVA2 glycolysis, viability, migration, and invasion [93]
Circ_0000677 oncogenic miR-106b-5p CCND1 proliferation [94]
Circ_0020123 oncogenic miR-144 ZEB1, EZH2 growth and metastasis [95]
Circ_0087862 oncogenic miR-1253 RAB3D tumor growth [96]
Circ_BANP oncogenic miR-503 LARP1 cancer growth, migration and invasion [97]
Circ_MAN2B2 oncogenic miR-1275 FOXK1 cell proliferation and invasion [98]
Circ_PIP5K1A oncogenic miR-600 HIF -1 α proliferation and metastasis [99]
Circ_PVT1 oncogenic miR-125b E2F2 Proliferation and Invasion [100]
Circ_CDR1 oncogenic miR-641 HOXA9 cell stemness [101]
Circ_103809 oncogenic miR-4302 MYC cell proliferation and invasion [63]
ZNF121
Circ_HIPK3 oncogenic miR-124 SphK1, STAT3, CDK4 cell survival, proliferation, cell death and apoptosis [64]
miR-149 FOXM1 cell proliferation and apoptosis [65]
Circ_PVT1 oncogenic miR-497 Bcl-2 aggressive clinicopathological characteristics and poor prognosis [66]
Circ_ZNF208 oncogenic miR-7-5p SNCA radio-sensitivity of patients to X-rays [67]
Circ_0046264 Tumor-suppressive miR-1245 BRCA2 apoptosis, proliferation and invasion [102]
Circ_100395 Tumor-suppressive miR-1228 TCF21 proliferation, migration and invasion [103]
Circ_cESRP1 Tumor-suppressive miR-93-5p CDKN1A sensitivity to chemotherapy [68]
Circ_FOXO3 Tumor-suppressive miR-155 FOXO3 cell proliferation, migration and invasion [104]
Colon
cancer		 Circ_ERBIN oncogenic miR-125a-5p,
miR-138-5p		 4EBP-1 growth and metastasis [105]
Circ_0000467 oncogenic miR-4766-5p KLF12 proliferation, metastasis, and angiogenesis [106]
Circ_0001313 oncogenic miR-510-5p AKT2 proliferation and apoptosis [71]
Circ_0001946 oncogenic miR-135a-5p - proliferation and metastasis [107]
Circ_0001982 oncogenic miR-144 - metastasis and poor prognosis [69]
Circ_0004277 oncogenic miR-512-5p PTMA cell apoptosis and cell proliferation [108]
Circ_0005963 oncogenic miR-122 PKM2 chemoresistance [109]
Circ_0007843 oncogenic mIR-518c-5p MMP2 migration and invasion [110]
Circ_000984 oncogenic miR-106b CDK6 cancer growth and metastasis [75]
Circ_0053277 oncogenic miR-2467-3p MMP14 cell proliferation, migration, and EMT [111]
Circ_0055625 oncogenic miR-106b-5p ITGB8 cell growth [72]
Circ_0060745 oncogenic miR-4736 CSE1L proliferation and metastasis [112]
Circ_CTNNA1 oncogenic miR-149-5p FOXM1 proliferation and invasion [113]
Circ_HIPK3 oncogenic miR-7 c-Myb cancer growth and metastasis [114]
Circ_HUWE1 oncogenic miR-486 - cell proliferation, migration and invasion [70]
Circ_NSD2 oncogenic miR-199b-5p DDR1, JAG1 migration and metastasis [76]
Circ_PRMT5 oncogenic miR-377 E2F3 proliferation [115]
Circ_PTK2 oncogenic miR-136-5p YTHDF1 proliferation, migration, invasion and chemoresistance [116]
Circ_UBAP2 oncogenic miR-199a VEGFA cell proliferation, migration, and invasion [77]
Circ_ACAP2 Tumor-suppressive miR-21-5p Tiam1 proliferation, migration, and invasion [117]
Liver
cancer		 Circ_0003141 oncogenic miR-1827 UBAP2 proliferation and invasion [118]
Circ_0056836 oncogenic miR-766-3p FOSL2 cell migration, proliferation and invasion [119]
Circ_0061395 oncogenic miR-877-5p PIK3R3 proliferation, invasion, and migration [120]
Circ_FBLIM1 oncogenic miR-346 FBLIM1 cell proliferation, apoptosis and invasion [121]
Circ_MAST1 oncogenic miR-1299 CTNND1 cell proliferation and migration [122]
Circ_MET oncogenic miR-30-5p Snail, DPP4, CXCL10 epithelial to mesenchymal transition [78]
Circ_ZNF566 oncogenic miR-4738-3p TDO2 cell migration, invasion, and proliferation [123]
circ_0000673 oncogenic miR-767-3p SET cell proliferation and invasion [124]
Circ_0001955 oncogenic miR-516a-5p TRAF6, MAPK11 tumor growth [79]
Circ_0016788 oncogenic miR-486 CDK4 proliferation, invasion and apoptosis [125]
Circ_0067934 oncogenic miR-1324 FZD5 proliferation, migration and invasion [126]
Circ_103809 oncogenic miR-377-3p FGFR1 proliferation, cycle progression and migration [127]
Circ_104348 oncogenic miR-187-3p RTKN2 proliferation, migration, invasion and apoptosis [128]
Circ_Cdr1as oncogenic miR-7 CCNE1, PIK3CD proliferation and invasion [129]
Circ_GFRA1 oncogenic miR-498 NAP1L3 growth and invasion [130]
Circ_HIPK3 oncogenic miR-124 AQP3 cell proliferation and migration [131]
Circ_MAT2B oncogenic miR-338-3p PKM2 glycolysis [132]
Circ_5692 Tumor-suppressive miR-328-5p DAB2IP tumor growth [80]
Circ_C3P1 Tumor-suppressive miR-4641 PCK1 tumor growth and metastasis [81]
Circ_HIAT1 Tumor-suppressive miR-3171 PTEN cell growth [82]
Gastric
cancer		 ciRS-133 oncogenic miR-133 PRDM16 white adipose browning [133]
Circ_0006282 oncogenic miR-155 FBXO22 cell growth, proliferation and metastasis [134]
Circ_0008035 oncogenic miR-375 YBX1 proliferation and invasion [135]
Circ_0002360 oncogenic miR-629-3p PDLIM4 proliferation, invasion and oxidative stress [85]
Circ_AKT3 oncogenic miR-198 PIK3R1 DNA damage repair and apoptosis [136]
Circ_CACTIN oncogenic miR-331-3p TGFBR1 tumor growth and EMT [137]
Circ_DLG1 oncogenic miR-141-3p CXCL12 proliferation, migration, invasion and immune evasion [138]
Circ_MTO1 oncogenic miR-199a-3p PAWR tumor growth, apoptosis, invasion and migration [139]
Circ_NHSL1 oncogenic miR-1306-3p SIX1, vimentin cell mobility, invasion and metastasis. [86]
Circ_NRIP1 oncogenic miR-149-5p AKT1 proliferation, migration and invasion [140]
Circ_PDSS1 oncogenic miR-186-5p NEK2 cell cycle and apoptosis [141]
Circ_PVRL3 oncogenic miR-203, miR-1272, miR-1283, miR-31, miR-638, miR-496, miR-485-3p, miR-766, and miR-876-3p - proliferation and migration [84]
Circ_0000039 oncogenic miR-1292-5p DEK proliferation, migration and invasion [142]
Circ_RanGAP1 oncogenic miR-877–3p VEGFA invasion and metastasis [143]
ciRS-7 oncogenic miR-7 PTEN, PI3K poor survival rate [144]
Circ_0026344 Tumor-suppressive miR-590-5p PDCD4 cell proliferation, migration and invasion [145]
Circ_CCDC9 Tumor-suppressive miR-6792-3p CAV1 tumor size, lymph node invasion, advanced clinical stage and survival rate [87]
Circ_LARP4 Tumor-suppressive miR-424-5p LATS1 cell proliferation and invasion [146]
Circ_MCTP2 Tumor-suppressive miR-99a-5p MTMR3 proliferation while promoting apoptosis of CDDP-resistant GC cells [147]
Circ_PSMC3 Tumor-suppressive miR-296-5p - the proliferation and metastasis [148]
Breast
cancer		 Circ_0001982 oncogenic miR-1287-5p MUC19 glycolysis, proliferation, migration, and invasion [149]
Circ_0001429 oncogenic miR-205 KDM4A metastasis [150]
Circ_0005230 oncogenic miR-618 CBX8 prognostic predictor [151]
Circ_0008039 oncogenic miR-515-5p CBX4 proliferation, migration and invasion [89]
Circ_0008039 oncogenic miR-432-5p E2F3 proliferation, cell-cycle progression and migration [90]
Circ_0136666 oncogenic miR-1299 CDK6 proliferation, migration and invasion [152]
Circ_100219 oncogenic miR-485-3p NTRK3 proliferation and migration [153]
Circ_ANKS1B oncogenic miR-148a-3p,
miR-152-3p		 USF1 metastasis [154]
Circ_BCBM1 oncogenic miR-125a BRD4 breast cancer brain metastasis [92]
Circ_CER oncogenic miR-136 MMP13 cell proliferation and migration [155]
Circ_FOXK2 oncogenic miR-370 IGF2BP3 migration and invasion [156]
Circ_MYO9B oncogenic miR-4316 FOXP4 cell proliferation and invasion [157]
Circ_PLK1 oncogenic miR-4500 IGF1 cell proliferation, migration and invasion [158]
Circ_RHOT1 oncogenic miR-106a-5p STAT3 malignant progression and ferroptosis [159]
Circ_RNF20 oncogenic miR-487a HIF-1 α proliferation, Warburg effect [91]
Circ_RPPH1 oncogenic miR-556-5p YAP1 proliferation, migration, invasion, and angiogenesis [160]
Circ_HIPK3 oncogenic miR-193a HMGB1, PI3K, AKT cell proliferation and invasion [161]
Circ_0000442 Tumor-suppressive miR-148b-3p PTEN tumor growth [162]
Circ_CCDC85A Tumor-suppressive miR-550a-5p MOB1A proliferation, migration and invasion [163]