Table 2.
List of miRNAs derived from transposable element (MDTEs) regulated by oncogenic and tumor-suppressive circular RNAs and its dysregulated target genes in various cancer types.
| Type of Circular RNA | Cancer Type | CircRNA Symbol /CircBase ID |
MicroRNA | Subclass | Super Family |
Target Gene | Cancer-Related Regulatory Process |
Ref. |
|---|---|---|---|---|---|---|---|---|
| Oncogenic circular RNA |
Bladder cancer | Circ_FARSA | miR-330-5p | SINE | MIR | - | cell proliferation, invasion, apoptosis and migration | [182] |
| Breast cancer | Circ_0007255 | miR-335-5p | SINE | MIR | SIX2 | inhibition of oxygen consumption, colony formation, cell migration and invasion | [183] | |
| Circ_0061825 (circ-TFF1) |
miR-326 | DNA transposon | hAT-Tip100 | TFF1 | cell proliferation, migration, invasion and EMT | [170] | ||
| Circ_ABCB10 | miR-1271 | LINE | L2 | - | proliferation and apoptosis | [184] | ||
| Cervical cancer | Circ_0067934 | miR-545 | LINE | L2 | EIF3C | proliferation, colony formation, migration, invasion and EMT | [185] | |
| Circ_0141539 (Circ_8924) | miR-518d-5p | LINE | RTE-BovB | CBX8 | cell proliferation, migration and invasion | [186] | ||
| Cholangiocarcinoma | Circ_0000284 | miR-637 | LINE | L1 | - | migration, invasion and proliferation | [171] | |
| Chronic lymphocytic leukemia | Circ_CBFB | miR-607 | SINE | MIR | FZD3 | proliferation and apoptosis | [187] | |
| Colon cancer | Circ_PIP5K1A | miR-1273a | SINE | Alu | AP-1, IRF-4, CDX-2, Zic-1 | cell viability, cell invasion and migration | [188] | |
| Circ_FARSA | miR-330-5p | SINE | MIR | LASP1 | cell growth | [181] | ||
| Circ_ALG1 | miR-342-5p | SINE | tRNA-RTE | PGF | metastasis | [189] | ||
| Circ_102958 | miR-585 | LTR | ERVL-MaLR | CDC25B | growth, migration and invasion | [190] | ||
| Glioma | Circ_0001982 | miR-1205 | SINE | MIR | E2F1 | cell proliferation, migration, invasion and cell cycle progression | [191] | |
| Circ_0034642 | miR-1205 | SINE | MIR | BATF3 | cell proliferation and invasion | [192] | ||
| Liver cancer | Circ_0000517 | miR-326 | DNA transposon | hAT-Tip100 | IGF1R | cell viability, colony formation, migration, invasion and glycolysis | [169] | |
| Circ_G004213 | miR-513b-5p | DNA transposon | hAT-Tip100 | PRPF39 | cisplatin sensitivity and prognosis | [193] | ||
| Circ_ 001306 | miR-584-5p | DNA transposon | hAT-Blackjack | CDK16 | cell proliferation and growth | [194] | ||
| Circ_ 104075 | miR-582-3p | LINE | CR1 | HNF4a | YAP-dependent tumorigenesis | [195] | ||
| Lung cancer | Circ_ FOXM1 | miR-1304-5p | SINE | Alu | PPDPF, MACC1 | proliferation and invasion | [196] | |
| Circ_ ZKSCAN1 | miR-330-5p | SINE | MIR | FAM83A | tumor growth | [180] | ||
| Circ_ 0004015 | miR-1183 | LINE | L2 | PDPK1 | proliferation, invasion, TKI drug resistance | [197] | ||
| Circ_ 0014130 | miR-493-5p | LINE | L2 | - | - | [198] | ||
| Circ_ POLA2 | miR-326 | DNA transposon | hAT-Tip100 | GNB1 | cell stemness and progression | [168] | ||
| Circ_ 0003998 | miR-326 | DNA transposon | hAT-Tip100 | Notch1 | cell proliferation and invasion | [167] | ||
| Osteosarcoma | Circ_ HIPK3 | miR-637 | LINE | L1 | HDAC4 | proliferation and migration and invasion | [173] | |
| Papillary thyroid cancer | Circ_ ZFR | miR-1261 | DNA transposon | TcMar-Tigger | C8orf4 | cell proliferation and invasion | [199] | |
| Stomach cancer | Circ-LDLRAD3 | miR-224-5p | DNA transposon | DNA transposon | - | cell growth, migration invasion and apoptosis | [178] | |
| Circ_HIPK3 | miR-637 | LINE | L1 | AKT1 | cell growth and metastasis | [172] | ||
| Circ_ATXN7 | miR-4319 | SINE | MIR | ENTPD4 | proliferation, invasion and apoptosis | [200] | ||
| Circ_0008287 | miR-548c-3p | DNA transposon | TcMar-Mariner | CLIC1 | immune escape of cancer cell | [201] | ||
| Tumor- Suppressive circular RNA |
Bladder cancer | Circ_ITCH | miR-224 | DNA transposon | DNA transposon | p21, PTEN | cell proliferation, migration, invasion and metastasis | [176] |
| Circ_HIPK3 | miR-558 | LTR | ERVL-MaLR | HPSE | migration, invasion, and angiogenesis | [202] | ||
| Breast cancer | Circ_AHNAK1 | miR-421 | LINE | L2 | RASA1 | proliferation and metastasis | [175] | |
| Colon cancer | Circ_SMARCA5 | miR-552 | LINE | L1 | - | growth, migration and invasion | [203] | |
| Liver cancer | Circ_SETD3 (circ_0000567) | miR-421 | LINE | L2 | MAPK14 | tumor cell growth | [174] | |
| Lung cancer | Circ_0078767 | miR-330-5p | SINE | MIR | RASSF1A | cancer cell viability, cell cycle progression and invasion | [179] | |
| Circ_0007059 | miR-378 | SINE | MIR | p53, CyclinD1, Bax, Cleaved-Caspase-3, E-cadherin, Vimentin, Twist, Zeb1 | proliferation and EMT | [204] | ||
| Osteosarcoma | Circ_0002052 | miR-1205 | SINE | MIR | APC2 | cell proliferation, migration, invasion and apoptosis | [205] | |
| Stomach cancer | Circ_FAT1(e2) | miR-548g | DNA transposon | TcMar-Mariner | YBX1 | cell proliferation, migration and invasion | [206] | |
| Circ_ZFR | miR-130a | LINE | RTE-BovB | PTEN | cell proliferation and apoptosis | [207] | ||
| Circ_0000096 | miR-224 | DNA transposon | DNA transposon | cyclin D1, CDK6, MMP-2, MMP-9 | cell growth and migration | [177] |