Table 1.

HNE-modified membrane proteins from erythrocytes of HH patients.

Protein Name	UniProt ID	Mascot Score	Spot	Patients	Nº Samples
▪ HH patients (blue)
Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 *	P62873	108	a	P2, P3	2
Unidentified			b	P2, P3, P5, P6	4
Actin, cytoplasmic 1 * and Actin, cytoplasmic 2 * (a)	P63261 P60709	117 117	d	P4, P5, P6	3
Ankyrin 1 (Fragment) Spectrin alpha chain, erythrocytic 1 * Spectrin beta chain (fragment)	H0YBS0 P02549 H0YJE6	271 121 113	f	P1, P2, P3, P6	4
Ankyrin 1 *	P16157	71	i	P1, P4, P5, P6	4
CD55 (Fragment) * CD44 Antigen *	H3BLV0 H0YD13	103 80	j	P1, P4, P5, P6	4
▪ HH patients and healthy individuals (red)
Unidentified			c	P2, P3, P5, P6, C1, C2	6
Band 3 anion transport protein	P02730	258	e	P2, C1, C2	3
Spectrin beta chain, erythrocytic Spectrin beta chain, erythrocytic	P11277 H0YJE6	306 356	h	P2, P3, P5, P6, C1	5
Spectrin beta chain, erythrocytic (fragment)	H0YJE6	356	g	P2, P5, C1, C2	4
Band 3 anion transport protein	P02730	248	l	P5, P6, C1, C2	4
▪ Healthy individuals (yellow)D
Band 3 anion transport protein	P02730	617	m	C1, C2	2

* Only found in HH patients. (a) These two accession numbers from UniProt were scored simultaneously since have an identity of 99% (371 in 375 residues, both of the same length) and as such were undistinguishable in the MADI-TOF/TOF spectra obtained for most of the fragments to discriminate both.