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Levels of Mg2+ required for wild-type and mutant gyrase enzymes to induce plasmid DNA cleavage in the presence of 50 µM ciprofloxacin (purple) or quinazolinedione (orange). Wild-type is shown in the top left, GyrAS83L in the top right, GyrAD87N in the bottom left, and GyrAS83A in the bottom right. Error bars represent the standard deviation of either two (WT, S83L, and D87N) or three (S83A) independent experiments.
