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. 2023 Feb 1;24(3):2791. doi: 10.3390/ijms24032791

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Reduction in Sts-induced activation of CASP3/7 by overexpression of XIAP in SH-SY5Y cells. (A) Kinetics of CASP3/7 activity in both SH-SY5Y^pcDNA3 (blue symbols) and SH-SY5Y^XIAP+ cells (red symbols), treated at time 0 with Sts (filled symbols) or vehicle (empty symbols). (B) The dot plot summarises the Sts effect in CASP3/7 activity for SH-SY5Y^pcDNA3 (blue symbols) and SH-SY5Y^XIAP+ cells (red symbols). Data were normalised by non-treated levels (dot line) after 30 min (dot plot represents means ± SEM; * = p-value < 0.05 in paired Student’s t-test for Sts-treated SH-SY5Y^pcDNA3 vs. vehicle-treated cells; † = p-value < 0.05 in a two-way ANOVA of genetic background effect; n = 3 independent experiments).