Figure 2.

Interactions among genes involved in CHD. The figure illustrates the physical interactions and participation in the same pathway of genes involved in CHD generation, obtained using the GeneMANIA software (version 3.6.0) [174,175] (available at: https://genemania.org/ (accessed on 27 January 2023)). The genes discussed in this review are represented by the striped circles depicted in the inner ring. They are connected to each other by lines of different colors, each indicating a specific type of interaction: pink for physical interactions and light blue for pathways. The outer ring shows genes closely related to those in the inner ring (according to the GeneMANIA software). These genes are represented as circles of different sizes according to their ranking, which is achieved by scoring them using label propagation. By inputting the names of the genes in GeneMANIA, it is possible to generate an image featuring active links that provide additional information about all interactions and relevant literature references.