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. 2023 Jan 31;12(3):1128. doi: 10.3390/jcm12031128

Table 2.

Baseline characteristics of quantiles of SIRI among the general adult population in NHANES, 1999–2018.

Variables Quartiles of SIRI p Value
Q1 Q2 Q3 Q4
Participants, n 10,684 10,732 10,725 10,734
Age, years 43.05 (17.06) 43.98 (17.48) 44.58 (17.99) 46.19 (19.47) <0.001
Male, % 4616 (43.2) 5031 (46.9) 5429 (50.6) 6007 (56.0) <0.001
Race/ethnicity, % <0.001
Mexican American 1797 (16.8) 2340 (21.8) 2297 (21.4) 2144 (20.0)
Other Hispanic 828 (7.7) 1013 (9.4) 975 (9.1) 911 (8.5)
Non-Hispanic White 2642 (24.7) 4105 (38.3) 4834 (45.1) 5448 (50.8)
Non-Hispanic Black 4075 (38.1) 2154 (20.1) 1645 (15.3) 1413 (13.2)
Other race 1342 (12.6) 1120 (10.4) 974 (9.1) 818 (7.6)
Education level, % <0.001
Below high school 2795 (26.2) 2969 (27.7) 2941 (27.4) 3010 (28.0)
High school 2229 (20.9) 2352 (21.9) 2400 (22.4) 2652 (24.7)
Above high school 5660 (53.0) 5411 (50.4) 5384 (50.2) 5072 (47.3)
Poverty, % 2348 (22.0) 2270 (21.2) 2258 (21.1) 2367 (22.1) 0.150
Smoking status, % <0.001
Never smokers 6897 (64.6) 6473 (60.3) 6151 (57.4) 5387 (50.2)
Former smokers 1905 (17.8) 2203 (20.5) 2177 (20.3) 2411 (22.5)
Current smokers 1882 (17.6) 2056 (19.2) 2397 (22.3) 2936 (27.4)
Drinking status, % <0.001
Non-drinkers 2716 (25.4) 2381 (22.2) 2281 (21.3) 2176 (20.3)
Low-to-moderate drinkers 7273 (68.1) 7598 (70.8) 7611 (71.0) 7523 (70.1)
Heavy drinkers 695 (6.5) 753 (7.0) 833 (7.8) 1035 (9.6)
BMI status, % <0.001
<25.0 3898 (36.5) 3469 (32.3) 3220 (30.0) 3285 (30.6)
25.0–29.9 3501 (32.8) 3616 (33.7) 3541 (33.0) 3429 (31.9)
>29.9 3285 (30.7) 3647 (34.0) 3964 (37.0) 4020 (37.5)
Physical activity, % <0.001
Inactive 2520 (23.6) 2560 (23.9) 2549 (23.8) 2882 (26.8)
Insufficiently active 3927 (36.8) 4078 (38.0) 4084 (38.1) 3968 (37.0)
Active 4237 (39.7) 4094 (38.1) 4092 (38.2) 3884 (36.2)
Energy intake, kcal/day 1913.00 [1439.00, 2503.00] 1955.05 [1467.00, 2570.38] 1977.00 [1496.68, 2586.00] 1999.00 [1498.00, 2631.97] <0.001
eGFR, ml/min/1.73 m2 103.09 (22.07) 100.83 (22.09) 99.40 (23.06) 96.91 (25.30) <0.001
ALT, U/L 20.00 [15.00, 27.00] 21.00 [16.00, 29.00] 21.00 [16.00, 29.00] 21.00 [16.00, 29.00] <0.001
AST, U/L 22.00 [19.00, 27.00] 22.00 [19.00, 27.00] 22.00 [19.00, 27.00] 22.00 [19.00, 27.00] 0.902
Hypertension, % 2642 (24.7) 2718 (25.3) 2860 (26.7) 3374 (31.4) <0.001
Diabetes, % 796 (7.5) 908 (8.5) 941 (8.8) 1131 (10.5) <0.001
WBC count, 103/μL 5.50 [4.70, 6.50] 6.50 [5.60, 7.60] 7.30 [6.30, 8.50] 8.60 [7.30, 10.10] <0.001
Neutrophils count, 103/μL 2.70 [2.20, 3.20] 3.60 [3.10, 4.20] 4.40 [3.70, 5.10] 5.60 [4.70, 6.70] <0.001
Monocyte count, 103/μL 0.40 [0.30, 0.50] 0.50 [0.40, 0.60] 0.60 [0.50, 0.70] 0.70 [0.60, 0.80] <0.001
Lymphocyte count, 103/μL 2.20 [1.80, 2.70] 2.10 [1.70, 2.60] 2.10 [1.70, 2.60] 1.90 [1.50, 2.40] <0.001
Platelet count, 103/μL 239.00 [203.00, 281.00] 246.00 [210.00, 289.00] 251.00 [214.00, 296.00] 258.50 [218.00, 305.00] <0.001
SII 291.19 [219.20, 375.67] 413.77 [332.81, 518.14] 523.89 [422.93, 653.14] 748.52 [590.89, 983.48] <0.001

Normally distributed continuous variables were described as means and SD, and continuous variables without a normal distribution were presented as medians [interquartile ranges]. Categorical variables were presented as numbers (percentages). eGFR, estimated glomerular filtration rate; ALT, alanine aminotransferase; AST, aspartate aminotransferase; WBC, white blood cell; SII, systemic immune-inflammatory index; SIRI, systemic inflammatory response index.