Table 4.
Multivariate logistic regression analysis of HOMA-IR to pregnancy outcomes.
| Variable | Non-Adjusted | Adjust I | Adjust II | |||
|---|---|---|---|---|---|---|
| Crude OR (95% CI) |
p-Value | Adjusted OR (95% CI) |
p-Value | Adjusted OR (95% CI) |
p-Value | |
| biochemical pregnancy | ||||||
| HOMA-IR | 0.99 (0.94, 1.04) | 0.626 | 0.99 (0.93, 1.05) | 0.727 | 1.00 (0.94, 1.06) | 0.914 |
| HOMA-IR Tercile | ||||||
| Low | 1 | 1 | 1 | |||
| Middle | 0.90 (0.66, 1.21) | 0.475 | 0.87 (0.63, 1.22) | 0.426 | 0.91 (0.65, 1.27) | 0.573 |
| High | 0.94 (0.70, 1.27) | 0.687 | 0.95 (0.67, 1.33) | 0.749 | 1.00 (0.70, 1.43) | 0.992 |
| HOMA-IR category | ||||||
| <2.56 | 1 | 1 | ||||
| ≥2.56 | 0.95 (0.74, 1.21) | 0.656 | 0.93 (0.70, 1.22) | 0.584 | 0.97 (0.73, 1.29) | 0.829 |
| clinical pregnancy | ||||||
| HOMA-IR | 0.98 (0.93, 1.03) | 0.406 | 0.99 (0.93, 1.05) | 0.687 | 0.99 (0.94, 1.05) | 0.829 |
| HOMA-IR Tercile | ||||||
| Low | 1 | 1 | 1 | |||
| Middle | 0.85 (0.63, 1.15) | 0.285 | 0.83 (0.59, 1.15) | 0.258 | 0.85 (0.61, 1.19) | 0.343 |
| High | 0.89 (0.66, 1.19) | 0.432 | 0.93 (0.66, 1.31) | 0.687 | 0.97 (0.68, 1.38) | 0.876 |
| HOMA-IR category | ||||||
| <2.56 | 1 | 1 | 1 | |||
| ≥2.56 | 0.90 (0.70, 1.15) | 0.388 | 0.90 (0.69, 1.19) | 0.477 | 0.94 (0.71, 1.24) | 0.658 |
| early miscarriage | ||||||
| HOMA-IR | 1.13 (1.02, 1.26) | 0.023 | 1.08 (0.96, 1.22) | 0.204 | 1.08 (0.96, 1.22) | 0.190 |
| HOMA-IR Tercile | ||||||
| Low | 1 | 1 | 1 | |||
| Middle | 1.89 (0.87, 4.10) | 0.107 | 2.07 (0.88, 4.90) | 0.097 | 2.07 (0.88, 4.85) | 0.096 |
| High | 2.56 (1.23, 5.32) | 0.012 | 2.40 (1.03, 5.58) | 0.042 | 2.33 (1.00, 5.44) | 0.049 |
| HOMA-IR category | ||||||
| <2.56 | 1 | 1 | 1 | |||
| ≥2.56 | 2.30 (1.27, 4.16) | 0.006 | 2.21 (1.13, 4.33) | 0.020 | 2.16 (1.11, 4.20) | 0.024 |
| miscarriage | ||||||
| HOMA-IR | 1.11 (1.02, 1.22) | 0.019 | 1.04 (0.94, 1.16) | 0.407 | 1.05 (0.94, 1.16) | 0.376 |
| HOMA-IR Tercile | ||||||
| Low | 1 | 1 | 1 | |||
| Middle | 1.37 (0.76, 2.47) | 0.295 | 1.08 (0.56, 2.10) | 0.820 | 1.09 (0.56, 2.10) | 0.805 |
| High | 1.89 (1.08, 3.29) | 0.025 | 1.35 (0.71, 2.56) | 0.363 | 1.32 (0.69, 2.53) | 0.401 |
| HOMA-IR category | ||||||
| <2.56 | 1 | 1 | 1 | |||
| ≥2.56 | 1.80 (1.14, 2.86) | 0.013 | 1.38 (0.81, 2.33) | 0.234 | 1.37 (0.81, 2.32) | 0.240 |
| live birth | ||||||
| HOMA-IR | 0.95 (0.90, 1.00) | 0.045 | 0.97 (0.91, 1.03) | 0.380 | 0.98 (0.92, 1.04) | 0.457 |
| HOMA-IR Tercile | ||||||
| Low | 1 | 1 | 1 | |||
| Middle | 0.85 (0.63, 1.16) | 0.304 | 0.90 (0.64, 1.26) | 0.532 | 0.93 (0.66, 1.31) | 0.687 |
| High | 0.75 (0.56, 1.03) | 0.072 | 0.87 (0.61, 1.25) | 0.455 | 0.92 (0.64, 1.32) | 0.641 |
| HOMA-IR category | ||||||
| <2.56 | 1 | 1 | 1 | |||
| ≥2.56 | 0.77 (0.60, 0.99) | 0.044 | 0.85 (0.64, 1.12) | 0.249 | 0.88 (0.66, 1.18) | 0.383 |
Model I adjusted for: age subgroups; BMI subgroups; AMH; basal FSH; AFC; PCOS phenotypes; protocol; endometrial thickness; embryo stage; embryo transferred number. Model II adjusted for: age; BMI; AMH; basal FSH; AFC; PCOS phenotypes; protocol; endometrial thickness; embryo stage; embryo transferred number. BMI, body mass index; AMH, anti-Müllerian hormone; FSH, follicle-stimulating hormone; AFC, antral follicle count; PCOS, polycystic ovary syndrome; HOMA-IR, homeostatic model assessment of insulin resistance.