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. 2023 Feb 1;24(3):2795. doi: 10.3390/ijms24032795

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Summary of IL-1 family cytokines and receptors discussed in this review for which there is evidence of involvement in the complications of prematurity: cardiopulmonary injury, brain injury, retinopathy of prematurity, necrotizing enterocolitis and sepsis. Reported evidence includes clinical associations (human infant) and therapeutic strategies investigated in animals (rodents and sheep). IL—interleukin; BAL—bronchoalveolar lavage; Ra—receptor antagonist; CSF—cerebrospinal fluid. Created with biorender.com.