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The interaction of differential cells, molecular factors, and transporters in the BBB under physiological (normal) or pathological (BBB breakdown) conditions. (BBB: blood–brain barrier, GLUT1: glucose transporter, LRP1: low-density-lipoprotein (LDL)-receptor-related protein 1, Pgp: phosphoglycolate phosphatase, RAGE: advanced glycosylation end product (AGE) receptor, MMP: matrix metalloproteinase, and PDGFRb: pericytes express platelet-derived growth factor receptor beta).
