Table 3.

Evolution of Self-Reported Long-COVID Symptoms over 1 Year of Follow-Up According to Initial SARS-CoV-2 Status.

	Month 6			Month 9			Month 12
Symptom	COVID+ No. (%)	COVID– No. (%)	P	COVID+ No. (%)	COVID– No. (%)	P	COVID+ No. (%)	COVID– No. (%)	P
Long-COVID	108/201 (53.7)	19/61 (31.2)	0.002	74/134 (55.2)	7/30 (23.3)	0.002	83/153 (54.3)	18/45 (40.0)	0.13
Difficulty concentrating	53/190 (27.9)	12/55 (21.8)	0.27	37/131 (28.2)	2/27 (7.4)	0.026	46/143 (32.9)	5/40 (12.5)	0.016
Asthenia	43/201 (21.4)	6/61 (9.8)	0.06	35/134 (26.1)	3/30 (10.0)	0.09	30/153 (19.6)	7/45 (15.6)	0.67
Sleep disorder	40/201 (19.9)	6/61 (9.8)	0.08	34/134 (25.4)	2/30 (6.7)	0.03	41/153 (26.8)	8/45 (17.8)	0.25
Headaches	28/201 (13.9)	4/61 (6.6)	0.18	15/134 (11.2)	1/30 (3.3)	0.31	21/152 (13.8)	6/45 (13.3)	1
Cough	19/201 (9.5)	3/61 (4.9)	0.43	15/134 (11.2)	0/30 (0.0)	0.08	14/153 (9.2)	6/45 (13.3)	0.41
Anosmia	18/201 (9.0)	1/61 (1.6)	0.09	12/134 (9.0)	0/30 (0.0)	0.13	11/151 (7.3)	1/44 (2.3)	0.31
Pruritis	18/201 (9.0)	2/61 (3.3)	0.18	9/134 (6.7)	3/30 (10.0)	0.46	13/151 (8.6)	2/45 (4.4)	0.53
Anxiety	13/196 (6.6)	4/57 (7.0)	1	6/133 (4.5)	1/29 (3.5)	1	8/150(5.3)	2/44 (4.6)	1
Dyspnea	12/201 (6.0)	0/61 (0.0)	0.07	7/134 (5.2)	0/30 (0.0)	0.35	6/153 (3.9)	2/45 (4.4)	1
Digestive disorders	12/201 (6.0)	2/461 (3.3)	0.53	7/134 (5.2)	0/30 (0.0)	0.35	8/152 (5.3)	0/45 (0.0)	0.20
Chest pain	7/32 (21.9)	-	-	4/27 (14.8)	-	-	3/29 (10.3)	-	-
Ageusia	5/201 (2.5)	0/61 (0.0)	0.59	3/134 (2.2)	0/30 (0.0)	1	3/151 (2.0)	1/44 (2.3)	1
	Mean (SD)	Mean (SD)		Mean (SD)	Mean (SD)		Mean (SD)	Mean (SD)
Number of symptoms	1.40 (1.72)	0.67 (1.29)	0.002	1.43 (1.70)	0.43 (0.97)	0.002	1.41 (1.84)	0.93 (1.64)	0.008

SD: standard deviation.