Table 4.
Relationship between adherence status and side effects experienced.
| Side effect experienced | n (%) | Adherence, 113 (83.7) | Nonadherence, 22 (16.3) | p value |
|---|---|---|---|---|
| Loss of energy drive | ||||
| No | 46 (34.1) | 32 (69.6) | 14 (30.4) | 0.001 |
| Yes | 89 (65.9) | 81 (91.0) | 8 (9.0) | |
| Feeling unmotivated | ||||
| No | 68 (50.4) | 53 (77.9) | 15 (22.1) | 0.068 |
| Yes | 67 (49.6) | 60 (89.5) | 7 (10.5) | |
| Day time sedation | ||||
| No | 59 (43.7) | 47 (79.7) | 12 (20.3) | 0.262 |
| Yes | 76 (56.3) | 66 (86.8) | 10 (12.2) | |
| Too much sleep | ||||
| No | 75 (55.6) | 62 (82.7) | 13 (17.3) | 0.715 |
| Yes | 60 (44.4) | 51 (85.0) | 9 (15.0) | |
| Muscle too stiff | ||||
| No | 100 (74.1) | 85 (85.0) | 15 (15.0) | 0.491 |
| Yes | 35 (25.9) | 28 (80.0) | 7 (20.0) | |
| Shaking | ||||
| No | 86 (63.7) | 70 (81.4) | 16 (18.6) | 0.336 |
| Yes | 49 (36.3) | 43 (87.8) | 6 (12.2) | |
| Jittery | ||||
| No | 94 (69.6) | 77 (81.9) | 17 (18.1) | 0.394 |
| Yes | 41 (30.4) | 36 (87.8) | 5 (12.2) | |
| Akathisia | ||||
| No | 104 (77.0) | 85 (81.7) | 19 (18.3) | 0.256 |
| Yes | 31 (23.0) | 28 (90.3) | 3 (9.7) | |
| Trouble waking up | ||||
| No | 66 (48.9) | 55 (83.3) | 11 (16.7) | 0.909 |
| Yes | 69 (51.1) | 58 (84.1) | 11 (15.9) | |
| Vision changes | ||||
| No | 96 (71.1) | 78 (81.2) | 18 (18.8) | 0.226 |
| Yes | 39 (28.9) | 35 (89.7) | 4 (10.3) | |
| Dry mouth | ||||
| No | 89 (65.9) | 74 (83.1) | 15 (16.9) | 0.807 |
| Yes | 46 (34.1) | 39 (84.8) | 7 (15.2) | |
| Drooling of saliva | ||||
| No | 115 (85.2) | 96 (83.5) | 19 (16.5) | 0.865 |
| Yes | 20 (14.8) | 17 (85.0) | 3 (15.0) | |
| Memory problems | ||||
| No | 72 (53.3) | 60 (83.3) | 12 (16.7) | 0.901 |
| Yes | 63 (46.7) | 53 (84.1) | 10 (15.9) | |
| Constipation | ||||
| No | 99 (73.3) | 85 (85.9) | 14 (14.1) | 0.261 |
| Yes | 36 (26.7) | 28 (77.8) | 8 (22.2) | |
| Weight changes | ||||
| Decrease | 24 (17.8) | 22 (91.7) | 2 (8.3) | 0.294 |
| Increase | 77 (57.0) | 65 (84.4) | 12 (15.6) | |
| No change | 34 (25.2) | 26 (76.5) | 8 (23.53) | |
| Sexual arousal | ||||
| No | 63 (46.7) | 53 (84.1) | 10 (15.9) | 0.901 |
| Yes | 72 (53.3) | 60 (83.3) | 12 (16.7) | |
| Menstrual changes | ||||
| No | 113 (83.7) | 97 (85.8) | 16 (14.2) | 0.128 |
| Yes | 22 (16.3) | 16 (72.7) | 6 (27.3) | |
| Total number of side effects experienced (mean, SD) | 6.8 (±3.0) | 7.0 (±2.9) | 5.9 (±3.3) | 0.136 |