Table 2.

Estimated the proportion of overdiagnosis based on overdiagnosis-embedded disease natural history model in three studies.

Study	Control group population	Mean of Follow-up time	Predicted CRC from the digital screened twin, E(t)	Observed CRC from the control group, U(t)	Overdiagnosis (%) (95% CI)
Invasive cancer only
Taiwan population-based study^a	5,417,699	11.0	66,339	63,616	4.16 (2.61,5.78)^c
Including HGD
Taiwan population-based study^a	5,417,699	11.0	79,469	72,587	9.90 (8.41,11.42)^c
UK trial	74,998	8.5	931	856	8.79 (8.28,9.65)
Demark trial	30,966	10.0	528	483	9.33 (8.81,10.20)
With consideration of adenoma removal
Taiwan population-based study^b	5,417,699	11.0	84,425	72,587	15.83 (15.23, 16.46)^c

^aWithout consideration of adenoma.

^bWith consideration of adenoma.

^cWith consideration of competing risk of death.