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. 2023 Feb 10;9:56. doi: 10.1038/s41420-023-01355-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A–C The effects of siRNA-NAT10 and its inhibitor Remodelin (B, C) on the apoptosis of Huh-7 cells and Hep3B cells after NAT10 knockdown and inhibition were analyzed by flow cytometry (n = 3). D Western blot showed the expression levels of Bax, Bak apoptotic protein, and Bcl-2 anti-apoptotic protein genes in Huh-7 and hep3B cells after NAT10 knockdown or inhibition. The effect of siRNA-NAT10 (E) and its inhibitor Remodelin (F, G) on the sensitivity of Huh-7 cells and Hep3B cells to Lenvatinib after NAT10 knockdown and inhibition was analyzed by flow cytometry (n = 3). H CCK-8 assay was used to study the effects of NAT10 knockdown or inhibition on the viability of Huh-7 and Hep3B cells treated with different concentrations of Lenvatinib for 24 and 48 h. I Photographic images of xenograft tumors collected (n = 5). J Schematic diagram of mouse xenograft tumor administration. K Average tumor volume and weight of xenograft mice in the groups on day 21. L HE staining of mouse metastatic tumors. All groups of cells were subjected to TM induction 24 h in advance, and each experiment was conducted three times. Data were shown as mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001.