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. 2023 Feb 10;9:56. doi: 10.1038/s41420-023-01355-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A The effects of Huh-7 and Hep3B cells treated with siRNA-HSP90AA1 on ERS marker genes were analyzed by WB. B HSP90AA1 was highly expressed in HCC tissues. C There was a positive correlation between HSP90AA1 and NAT10 in HCC tissues. D High HSP90AA1 expression was significantly associated with shorter OS, PPS, and DSS. E There was a positive correlation between HSP90AA1 and ERS marker proteins GRP78, ATF-6, and PERK in HCC tissues. F Photographic images of xenograft tumors collected (n = 6). G Average tumor volume and weight of xenograft mice in the Control and Remodelin groups on day 21. H Western blot showed that the protein levels of NAT10 and HSP90AA1 were decreased in tumor tissues of xenograft mice. I qRT-PCR showed that both NAT10 mRNA and HSP90AA1 mRNA decreased in tumor tissues of xenograft mice treated with Remodelin. J HE staining of mouse metastatic tumors. K IHC staining showed that the protein levels of NAT10, GRP78, and HSP90AA1 in tumor tissues of Remodelin-treated xenografts were decreased. All data were shown as mean ± standard deviation. *P < 0.05, **P < 0.01, ***P < 0.001.