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. 2023 Feb 10;14:755. doi: 10.1038/s41467-023-36089-9

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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Fig. 3 — a–h HFD-fed Cdx2Apc^f/w mice were colonized with heat-killed B. fragilis 9343 (HBF) or B. fragilis 9343 (BF) for 12 weeks (n = 7 mice for HBF; n = 9 mice for BF). a Length of colon. The ileum (b) and colon (c) tumor incidence, and tumor numbers with different sizes (<4 mm², >4 mm² and the sum of both). Mann–Whitney U test with two-sided. d Total tumor number in the intestine. Two-tailed Student’s t test. e, f Representative pictures of colon (left), gross images of tumor (top right) in the colon and H&E staining (bottom right) of colon tumor sections. Scale bars: 1.5 mm (top right) and 100 μm (bottom right). g Unconjugated bile acid profiles in the colon contents. Mann–Whitney U test with two sided. h Total unconjugated bile acid levels in the colon contents. Two-tailed Student’s t test. i Relative mRNA levels of WNT target genes in non-tumor (NT) and tumor (T) colon tissues (n = 7 for HBF-NT; n = 9 for BF-NT; n = 5 for HBF-T; n = 9 for BF-T;). Kruskal–Wallis test with Dunn’s post hoc test. j WB data of proteins encoded by WNT target genes, n = 3 independent samples/group. k Representative IHC staining of Ki-67, a proliferation marker (n = 5 independent slides for HBF; n = 7 independent slides for BF). Scale bars: 100 μm. Data are presented as mean values +/− SEM in (a–d, g–i). Source data are provided as a Source Data file for Fig. 3.