Table 3.

Mendelian Randomization estimates between plasma vitamin D concentrations and total or colorectal cancer.

MR method	Odds ratio (95% CI) with 110 SNPs	p value	Odds ratio (95% CI) with 14 SNPsa	p value
Total cancer
IVW	0.83 (0.63–1.09)	0.18	0.88 (0.64–1.22)	0.45
MR Egger	0.83 (0.57–1.19)	0.31	0.91 (0.43–1.90)	0.80
Egger intercept	–	0.96	–	0.93
Weighted median	0.91 (0.62–1.34)	0.63	0.91 (0.62–1.35)	0.64
Colorectal cancer
IVW	1.00 (0.80–1.24)	0.98	1.05 (0.82–1.34)	0.71
MR Egger	1.01 (0.75–1.37)	0.93	1.09 (0.62–1.90)	0.77
Egger intercept	–	0.88	–	0.88
Weighted median	1.08 (0.79–1.48)	0.62	1.09 (0.80–1.47)	0.60

IVW Inverse variance weighted, MR Egger Mendelian randomization egger.

ORs were per 1 unit increment in log₂-transformed Vitamin D concentrations.

^a14 SNPSs (p < 0.05) were rs3755967, rs10832254, rs12803256, rs2144530, rs3814995,rs1229984, rs4575545, rs6724965, rs7519574, rs8121940, rs2012736, rs8091117, rs35823191, and rs11732896 in Table 2.