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. 2023 Feb 10;6:164. doi: 10.1038/s42003-023-04543-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Time courses of body weight (a) and Kaplan–Meier survival curves (b) in nude rats in the tumorigenicity study. Intact: control nude rat without surgery (n = 4). Sham: control nude rat with subretinal injection of vehicle control (n = 4). Transplanted: nude rat with subretinal transplantation of a single iPSC-Q-derived retinal sheet (n = 4). Data are presented as mean ± SE. c, d HE staining of transplanted eye sections at 13, 26, 52, and 78 weeks after transplantation. Scale bar: 100 µm. e–h Immunostaining of transplanted eye sections for human nuclear markers, retinal markers, and Ki67. Scale bar: 20 µm. e Immunostaining for HuNu (green), Recoverin (red), Chx10 (white), and DAPI (blue). f Immunostaining for human Ku80 (green), Ki67 (red), and DAPI (blue). g High-magnification image of immunostaining for the graft (52 weeks) with antibodies for human Ku80 (green), Ki67 (red), and DAPI (blue). Arrow indicates Ki67⁺ and Ku80⁺ cells. h Percentages of Ki67⁺ and Ku80⁺ cells among the Ku80⁺ human cells. Data are presented as mean. INL inner nuclear layer.