Table 3.

The AAR incidence in patients with different ICM injection parameters

		Conventional assessment group (%)	SAW group (%)	P value	RD (95% CI)
Types of ICM	IOCM	0.69 (129/18,614)	0.47 (82/17,437)	0.01	0.22 (0.07, 0.38)
	LOCM	0.37 (377/102,208)	0.25 (332/132,906)	< 0.001	0.12 (0.07, 0.17)
	P value	< 0.001	< 0.001
IOCM	Mild AAR	0.63 (117/18,614)	0.46 (80/17,437)	0.03	0.17 (0.02, 0.32)
	Moderate AAR	0.06 (11/18,614)	0.005 (1/17,437)	0.01	0.05 (0.02, 0.10)
	Severe AAR	0.005 (1/18,614)	0.005 (1/17,437)	1.00	0 (− 0.03, 0.03)
LOCM	Mild AAR	0.34 (343/102,208)	0.24 (319/132,906)	< 0.001	0.10 (0.05, 0.14)
	Moderate AAR	0.03 (28/102,208)	0.008 (10/132,906)	< 0.001	0.02 (0.01, 0.03)
	Severe AAR	0.006 (6/102,208)	0.002 (3/132,906)	0.29	0.004 (0, 0.01)
Injection dose	< 100 mL	0.39 (413/104,971)	0.28 (385/138,702)	< 0.001	0.12 (0.07, 0.16)
	≥ 100 mL	0.60 (73/12,264)	0.25 (29/11,596)	< 0.001	0.35 (0.18, 0.52)
	P value	0.01	0.59
Injection speed	< 5 mL/s	0.34 (238/70,835)	0.27 (262/97,967)	0.01	0.07 (0.02, 0.12)
	≥ 5 mL/s	0.57 (245/42,878)	0.29 (152/52,332)	< 0.001	0.28 (0.20, 0.37)
	P value	< 0.001	0.42

ICM, iodinated contrast media; AAR, acute adverse reactions; SAW, stratified assessment and warning; RD, rate difference; CI, confidence interval; LOCM, low-osmolality contrast media; IOCM, iso-osmolality contrast media