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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Mol Psychiatry. 2022 Oct 12;28(2):611–624. doi: 10.1038/s41380-022-01820-3

Figure 2. Sex-selective and exposure age-dependent effects of PreP-S vs. PostP-S on adult ventral hippocampus (vHipp) pyramidal neuron activity.

Figure 2.

(A) Experimental timeline, representative spike waveform, and 10-sec sample firing of identified vHipp neurons. vHipp pyramidal neurons (PNs) were identified based on low firing rate (<10Hz) and long spike duration (>2.2ms). (B) No change in the number of vHipp putative PNs detected per electrode track. (C) PreP-S selectively increased vHipp PN firing rate in males whereas PostP-S selectively increased PN firing rate in females. (D) PreP-S selectively increased percent of vHipp spikes occurring in bursts (defined by interspike interval <80ms) in males. Violin plots were provided (here and in subsequent figures) to indicate datasets that contain non-normally distributed group data. Accordingly, Kruskal–Wallis analysis of group median differences followed by Dunn’s multiple-comparison test was used. Data are presented as median (solid red line) and quartiles (dashed red line). *p<0.05; **p<0.01.