. Author manuscript; available in PMC: 2024 Mar 1.

Published in final edited form as: Adv Anat Pathol. 2022 Dec 20;30(2):104–111. doi: 10.1097/PAP.0000000000000391

Table 2:

Novel immunohistochemical studies and their diagnostic utilization in IDH2 mutated sinonasal tumors.

Mutation	11C8B (strong diffuse granular cytoplasmic)	mIDH1/2 (strong granular cytoplasmic)	MsMab-1 (strong diffuse granular cytoplasmic)	3C11 (strong diffuse granular cytoplasmic)	MMab1 (strong diffuse granular cytoplasmic)
R172S	16/16	4/4	7/7	0/4	0/4
R172T	2/2	3/4^b	-	0/1	0/4
R172G	0/1	2/2	4/4	1/1	0/1
R172M	0/1	-	1/1^d	0/1	1/1
R132C^a	-	0/1	1/1^d	1/1^f	0/1
Unknown		15/15^c	3/3 ^e	-	-

Bold: strong positive;

R132C of IDH1;

Weak granular in 2 cases and negative in one case;

mIDH1/2 was only used (11 SNUC-cases were strong positive, 3 SNUC were weak granular and 1 PDC was weak granular);

Weak to moderate cytoplasmic;

One case of (SNEC, ITAC and HG-Non-ITAC);

Smooth cytoplasmic in IDH1-mutated intrahepatic cholangiocarcinoma; SNUC: sinonasal undifferentiated carcinoma, PDC: poorly differentiated carcinoma, SNEC: small cell neuroendocrine carcinoma, ITAC: Intestinal-type adenocarcinoma and HG-Non-ITAC: high grade non-intestinal-type adenocarcinoma.