Table 2.

GL-3 scores in SSCE, assessed by light microscopy, at baseline and at Weeks 12, 26, 52, and 156, and fractions of cytoplasm volume occupied by GL-3 inclusions, as assessed by electron microscopy, at baseline and at Weeks 12, 26, and 156.

Patient #b	GL-3 scores in SSCE (light microscopy)a, and fractions of cytoplasm volume of SSCE occupied by GL-3 inclusions (electron microscopy, italic)
	Baseline	Week 12	Week 26	Week 52 (optional)	Week 156
1	2	1	1	1	1
	0.296	0.331	0.249	-	0.144
2	1	1	1	1	NS
	0.254	0.287	0.254	-	-
3	2	1	1	2	1
	0.329	0.374	0.276	-	0.210
4	1	1	1	NS	0
	0.304	0.303	-		0.171
5	1	NS	NS	NS	NS
	-
6	2	1	1	NS	NS
	0.271	0.221	0.221
7	1	1	1	NS	NS
	0.307	0.335	0.210
8	1	2	2	1	0
	0.296	0.234	0.200	-	0.200
9	1	1	1	1	1
	0.257	0.218	0.170	-	0.205
10	2	2	2	1	1
	0.329	0.297	0.262	-	0.168
11	1	NS	NS	NS	NS
	-

^aGL-3 inclusions scoring: 0=no/trace; 1=mild; 2=moderate.

^bPatient numbers randomly assigned.

GL-3, globotriaosylceramide; NS, no sample; SSCE, superficial skin capillary endothelium.