Fig. 3.

The SIA is a prognostic predictor in bladder cancer, gastroesophageal cancer, lung adenocarcinoma and melanoma (See also Supplementary Table S3). (a) Overall survival stratified by SIA in seven tumour types. Tissue microarrays encompassing 94–295 cases of the respective tumour type were stained and the patients in each cohort stratified in terciles according to SIA score, except melanoma, which was stratified in two groups split by the median. Statistical analysis by log-rank test for three groups, and/or Cox regression for pairwise comparison (high vs low and intermediate vs low). Insert tables demonstrate significance of SIA in female or male patients. (b) Overall survival stratified by IS in 7 tumour types. Statistical analysis performed by log-rank test for three groups. (c) Comparison of the predictive accuracy of IS and SIA for OS in 7 tumour types, generated using tAUC analysis. Statistical analysis performed for the evaluation of the difference between the survival models of AUC and IS: the statistically significant time-points are indicated by asterisks; (d) The OS predictive ability of SIA and IS in 8 analysed tumour types.