Figure 2.

Variant subgroups based on donor status. This schematic identifies subgroups of patients with MDS/HSCT recipients based on the presence or absence of a predisposing variant, the manner of inheritance, whether the variant is shared by the donor and would be disease-causing, as well as subgroups chosen for statistical analyses of outcome parameters. ^†Healthy carriers refer to recipients with a P/LP variant who received donor stem cells lacking an AD P/LP variant or cells with a heterozygous P/LP allele with an AR mode of inheritance. AD, autosomal dominant; AR, autosomal recessive; het, heterozygous; HSCT, hematopoietic stem cell transplantation; LP, likely pathogenic; MDS, myelodysplastic syndrome; mut, mutated; P, pathogenic; wt, wild-type.