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Schematic illustration of baicalein-induced G2/M cell cycle arrest in ErbB2-positive ovarian cancer cells via activation of the ATM/CHK2/CDC25C signaling axis. Treatment of ovarian cancer cells with baicalein induces ROS generation, causes DNA double-strand breaks, and triggers the DNA damage response to ATM signaling to arrest cell cycle progression at the G2/M phase. Blue font represents an increase, and orange font represents a decrease.
