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. 2023 Feb 3;28(3):1470. doi: 10.3390/molecules28031470

Figure 4.

Figure 4

(a) Schematic illustration of pillar[5]arene-based amphiphilic supramolecular brush polymers for targeted drug delivery (I). Blood circulation time of mice after injection of DOX·HCl and DOX-loaded nanoparticles (II). Tumor growth inhibition curves in tumor-bearing mice with different formulations (III) (* p < 0.05, ** p < 0.01). (reproduced with permission of Royal Society of Chemistry from ref. [122]). (b) Schematic illustration of dual-responsive controlled assembly and release of drugs in vesicles (I). Cytotoxicity of vesicles at different concentrations to MCF-7 cells (II). Effects of DOX·HCl-loaded vesicles and free drugs on proliferation of MCF-7 cells in vitro (III). (reproduced with permission of Elsevier from ref. [132]).