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. 2023 Feb 2;28(3):1428. doi: 10.3390/molecules28031428

Table 2.

Antiviral Potencies in Cells Infected with HIV-1 Vectors Bearing the S230N IN Mutant i.

R No EC50 (nM) No EC50 (nM) Ratio ii
graphic file with name molecules-28-01428-i010.jpg 6c WT 4.8 ± 0.9
S230N 9.3 ± 1.9		 7c WT 31.7 ± 2.8
S230N 38.0 ± 3.8		 6.64.08
graphic file with name molecules-28-01428-i011.jpg 6d WT 10.8 ± 1.7
S230N 15.4 ± 0.3		 7d WT 54.5 ± 3.0
S230N 97.0 ± 16.9		 5.06.29
graphic file with name molecules-28-01428-i012.jpg 6e WT 16.6 ± 2.0
S230N 30.7 ± 1.4		 7e WT 75.7 ± 7.4
S230N 100.8 ± 17.5		 4.63.28

i EC50 values obtained from cells infected with lentiviral vector in which IN contains the S230N mutant. ii Ratio of the antiviral potencies after and before hydrogenation.