Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The selected ADME parameters for the tested compounds.
| Parameters Observed | Tested Compounds | ||
|---|---|---|---|
| NAR | EIC | OCT | |
| Water solubility (log mol/L) | −2.891 | −8.525 | −7.085 |
| Caco-2 permeability (log Papp in 10−6 cm/s) | −0.68 | 1.38 | 1.114 |
| Skin permeability (log Kp) | −2.735 | −2.78 | −2.743 |
| BBB permeability (log BB) | −2.034 | 1.03 | 1.166 |
| CNS permeability (log PS) | −4.911 | −0.937 | −0.762 |
| Max. tolerated dose (human) (log mg/kg/day) | 0.323 | −0.188 | −0.284 |
| Hepatotoxicity | No | No | No |
| Skin sensitization | No | Yes | Yes |
