Table 2.
Metabolic regulation mechanism of Polygonati Rhizoma polysaccharides.
| Model | Active Components | Dose | Putative Mechanism | References |
|---|---|---|---|---|
| NCI-H716 cells | Polygonatum polysaccharides | 25–100 μg/mL for 2h | stimulate GLP-1 production | [58] |
| HepG2 cells | PKPs-1 | 0.78–100 mg/L for 24 h | upregulate the levels of Glu utilization efficiency | [66] |
| STZ-induced diabetic mice | PKPs-1 | 1190 mg/kg once daily for 15 consecutive days | improve insulin tolerance; affect metabolism of serum lipids; activate PI3K/AKT signaling pathway; increase expression of IRS-1, PI3K, and AKT | [66] |
| STZ-induced diabetic SD rats | PSP | 200–800 mg/kg·d for 12 weeks | lower levels of FBG and glycated hemoglobin; improve polydipsia, polyphagia, polyuria and weight loss; delay cataract progression; suppress oxidative stress reaction; alleviate retinal vasculopathy; elevate levels of insulin and C-peptide in plasma; inhibit formation of advanced glycosylation end products | [108] |
| T2DM rats | PKP | 0.1 g/kg for 56 days | increase the content of fasting insulin and lowered the levels of FBG | [109] |
| IR-3T3-L1 adipocytes | PSP | 50–250 µg/mL | alleviate inflammatory cytokines; promoting Nrf2 expression | [110] |