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Basic reaction mechanisms of glutathione peroxidase (GPx), and glutaredoxin in (de)glutathionylation using (GSH)GSSG, respectively, and reduction of GSSG by the activity of glutathione reductase (GR) with reducing the power of NADPH + H+. Reduction of peroxiredoxin (Prdx) after disposal of peroxides is ensured by thioredoxin (Trx), which is reduced by consumption of NADPH + H+ in catalytic efficiency of thioredoxin reductase (TrxR).
