Table 2.

Dextran applications in drug-delivery systems.

DDS Type	Drug Loaded	Targeted Disease/Applications	Observations	Reference
Hydrogel	Polydopamine	Multidrug-resistant bacterial infections	Good physical and chemical properties; low cytotoxicity against mouse fibroblast cells; precise in vivo antibacterial and wound-healing performance	[41]
Nanohydrogel matrix	Maghemite		Magnetic properties; high drug loading and stability in the circulatory system	[97]
Hydrogel	Aniline trimer elastomer	Smart DDS for localised drug release	Controllable swelling ratio; stable rheological properties; good conductivity; electric stimuli-dependent activity	[10]
Nanogel	Methotrexate	HeLa cells	Sensitive to the variation of the pH and redox environment; high release rate at pH 5.0; suitable carriers for cancer chemotherapeutics	[98]
Magnetic microgels	Doxorubicin		Promising results for further studies	[99]
Nanogels	Doxorubicin	H1299 cancer cell line	The indisputable results promote this system for further in vivo testing	[100]
Hydrogels	Praziquantel	Anthelmintic disease	Good in vitro results	[28]
Hydrogels	OndansetronTM	Antiemetic following chemotherapy	Good release kinetics’ curve	[101]
Cryogels	Vitamin B12	Vitamin B12 deficiencies	Suitable carriers for water-soluble biomolecules’ delivery	[102]
Micro-hydrogel	Indole; 3-nitrophenol; hydroxybenzoic acid; diclofenac;		Very satisfactory release kinetics’ curve	[2]
Nanohydrogels	Ornidazole	Clostridium sp. infections	Very good in vitro antibiotic effect	[103]
Nanogel	Curcumin	New foods development	In vitro simulations showed sustained drug release	[104]
Nanogel		Food ingredient preparation	High potential for hydrophobic bioactive compounds’ encapsulation	[105]
Hydrogels	Arginine-glycine-aspartic acid (RGD) sequences	Artificial cardiac tissues	Promising system for building cardiac grafts	[19]
Hydrogels	RGD and activin A	Ovarian tissue culture	Significantly improves follicular oocytes’ in vitro maturation and development; synergistic effects in 3D tissue culture development	[106]