Table 2.
DNA polymorphisms associated with sarcopenia-related traits, fat percentage and type 2 diabetes.
| Gene/Near Gene | SNP | Protective Allele |
Risk Allele |
p Value | ||||
|---|---|---|---|---|---|---|---|---|
| Handgrip Strength | Appendicular Lean Mass | Usual Walking Pace | Body Fat Percentage | Type 2 Diabetes | ||||
| GDF5 | rs143384 | G | A | 5.5 × 10−46 | 7.0 × 10−319 | 4.0 × 10−8 | NS | NS |
| POLD3 | rs72977282 | T | A | 7.4 × 10−28 | 9.3 × 10−8 | 3.6 × 10−3 | NS | NS |
| LCORL | rs1472852 | C | A | 4.0 × 10−24 | 8.2 × 10−135 | 3.7 × 10−4 | 3.0 × 10−5 | NS |
| ADCY3 | rs10203386 | T | A | 1.6 × 10−23 | 1.7 × 10−36 | 3.3 × 10−3 | 2.4 × 10−38 | NS |
| DLEU1 | rs3116602 | T | G | 1.4 × 10−21 | 9.5 × 10−155 | 8.7 × 10−4 | NS | NS |
| AOC1 | rs6977416 | A | G | 6.7 × 10−19 | 1.4 × 10−113 | 7.7 × 10−4 | 5.6 × 10−10 | NS |
| SLC39A8 | rs13107325 | C | T | 2.0 × 10−17 | 3.9 × 10−3 | 1.8 × 10−21 | 5.0 × 10−23 | 1.1 × 10−4 |
| HLA-DRB1 | rs34415150 | A | G | 3.4 × 10−17 | 2.5 × 10−17 | 2.3 × 10−5 | 6.6 × 10−4 | 6.0 × 10−17 |
| HLA-DRB1 | rs2760975 | G | A | 4.6 × 10−17 | 1.7 × 10−17 | 1.6 × 10−5 | 8.4 × 10−6 | 6.9 × 10−10 |
| MLLT10 | rs1243182 | C | T | 3.5 × 10−16 | 2.6 × 10−3 | 3.9 × 10−7 | 6.5 × 10−14 | NS |
| PRRC2A | rs2260051 | A | T | 1.0 × 10−15 | 5.2 × 10−6 | 2.6 × 10−5 | 3.3 × 10−17 | 1.7 × 10−13 |
| BTNL2 | rs2213581 | T | C | 1.1 × 10−15 | 4.3 × 10−20 | 6.3 × 10−4 | 3.3 × 10−6 | 3.2 × 10−11 |
| FKBPL | rs41268905 | G | A | 2.4 × 10−15 | 8.9 × 10−17 | 4.0 × 10−4 | 1.3 × 10−5 | NS |
| ZBTB38 | rs2871960 | C | A | 4.0 × 10−15 | 2.2 × 10−135 | 1.0 × 10−3 | NS | 9.5 × 10−5 |
| ADCY3 | rs1056074 | T | C | 7.6 × 10−15 | 1.2 × 10−11 | 1.3 × 10−3 | 1.8 × 10−17 | NS |
| PML | rs5742915 | C | T | 1.8 × 10−14 | 9.3 × 10−39 | 4.0 × 10−5 | 4.1 × 10−8 | 1.6 × 10−3 |
| POU6F2 | rs4549685 | T | C | 4.5 × 10−14 | 4.0 × 10−7 | 7.3 × 10−5 | 2.1 × 10−12 | 1.5 × 10−4 |
| HMGA2 | rs4338565 | C | T | 8.0 × 10−14 | 4.9 × 10−151 | 2.3 × 10−4 | NS | 1.4 × 10−3 |
| HLA-DRB1 | rs113315602 | A | C | 1.4 × 10−12 | 1.0 × 10−5 | 5.4 × 10−4 | 3.5 × 10−6 | NS |
| WWP2 | rs4985445 | A | G | 1.4 × 10−12 | 3.3 × 10−20 | 1.2 × 10−5 | 4.6 × 10−18 | 1.7 × 10−5 |
| MTCH2 | rs11039324 | G | A | 3.5 × 10−12 | 7.3 × 10−26 | 3.9 × 10−15 | 9.0 × 10−38 | 3.2 × 10−6 |
| HLA-DRB5 | rs117108573 | C | T | 3.6 × 10−11 | 1.1 × 10−4 | 7.4 × 10−4 | 3.4 × 10−4 | NS |
| GBF1 | rs2273555 | G | A | 4.1 × 10−11 | 8.1 × 10−5 | 8.2 × 10−5 | NS | NS |
| SFMBT1 | rs62253653 | G | A | 9.5 × 10−11 | 3.0 × 10−3 | 1.0 × 10−7 | 4.0 × 10−3 | 1.2 × 10−3 |
| JARID2 | rs2237149 | A | C | 7.5 × 10−10 | 4.5 × 10−5 | 1.8 × 10−4 | 6.4 × 10−6 | NS |
| ADPGK | rs4776614 | C | G | 1.9 × 10−9 | 8.4 × 10−6 | 1.4 × 10−4 | 5.6 × 10−13 | NS |
| JUND | rs7249 | T | C | 2.0 × 10−9 | 1.2 × 10−6 | 2.6 × 10−4 | 5.8 × 10−13 | NS |
| KIF1B | rs3903151 | G | A | 2.6 × 10−9 | 1.3 × 10−16 | 3.0 × 10−4 | 1.2 × 10−4 | 2.9 × 10−3 |
| SWT1 | rs10797999 | T | C | 3.0 × 10−9 | 1.4 × 10−5 | 1.4 × 10−8 | 2.5 × 10−4 | NS |
| FOXP1 | rs4677611 | T | C | 3.2 × 10−9 | 2.4 × 10−4 | 2.2 × 10−3 | 2.3 × 10−5 | NS |
| SOX5 | rs11047225 | C | T | 8.5 × 10−9 | 4.3 × 10−10 | 2.2 × 10−3 | NS | NS |
| NCOA1 | rs77012907 | A | G | 1.2 × 10−8 | 1.2 × 10−13 | 5.8 × 10−4 | 2.9 × 10−15 | NS |
| MMS22L | rs9320823 | T | C | 1.4 × 10−8 | 7.9 × 10−10 | 1.1 × 10−6 | 3.9 × 10−22 | 1.5 × 10−4 |
| ZKSCAN5 | rs3843540 | C | T | 2.3 × 10−8 | 5.8 × 10−6 | 1.1 × 10−4 | 4.0 × 10−9 | NS |
| MLN | rs12055409 | G | A | 3.5 × 10−8 | 3.6 × 10−3 | 1.8 × 10−3 | 3.2 × 10−7 | 4.4 × 10−4 |
| FOXP1 | rs830643 | A | G | 4.0 × 10−8 | 9.7 × 10−7 | 2.9 × 10−7 | 5.7 × 10−8 | 9.3 × 10−6 |
| GADD45G | rs1329733 | A | G | 4.3 × 10−8 | 2.2 × 10−4 | 6.4 × 10−5 | 9.0 × 10−13 | NS |
| IL11 | rs4252548 | C | T | 6.2 × 10−8 | 4.8 × 10−35 | 2.6 × 10−3 | NS | NS |
| COMMD4 | rs11636600 | G | A | 6.8 × 10−8 | 5.0 × 10−13 | 9.7 × 10−11 | NS | NS |
| HABP4 | rs6477489 | C | A | 7.2 × 10−8 | 5.2 × 10−59 | 3.7 × 10−3 | 1.1 × 10−3 | NS |
| GLCCI1 | rs12702693 | T | C | 1.8 × 10−7 | 6.6 × 10−20 | 1.4 × 10−3 | NS | NS |
| H1FX | rs4073154 | G | A | 2.5 × 10−7 | 1.9 × 10−33 | 3.3 × 10−8 | NS | NS |
| CEP192 | rs1786263 | G | T | 3.1 × 10−7 | 1.0 × 10−22 | 2.3 × 10−3 | 5.5 × 10−7 | NS |
| PPARD | rs3734254 | T | C | 5.2 × 10−7 | 2.3 × 10−33 | 5.6 × 10−6 | NS | NS |
| ZNF568 | rs1667369 | A | C | 1.3 × 10−6 | 1.5 × 10−10 | 2.7 × 10−8 | 1.7 × 10−3 | NS |
| SERPINA1 | rs28929474 | T | C | 3.5 × 10−6 | 1.1 × 10−14 | 3.4 × 10−4 | NS | 2.6 × 10−3 |
| NMT1 | rs2301597 | C | T | 4.6 × 10−6 | 4.8 × 10−33 | 2.7 × 10−9 | 1.3 × 10−8 | NS |
| PIEZO1 | rs2968478 | T | G | 5.1 × 10−6 | 5.6 × 10−14 | 2.8 × 10−3 | NS | NS |
| CELF4 | rs12962050 | A | G | 6.8 × 10−6 | 1.5 × 10−14 | 4.8 × 10−4 | 2.1 × 10−3 | NS |
| BCKDHB | rs9350850 | C | T | 7.5 × 10−6 | 2.9 × 10−24 | 1.3 × 10−3 | NS | NS |
| E2F3 | rs4134943 | T | C | 9.9 × 10−6 | 2.0 × 10−8 | 4.9 × 10−9 | 6.7 × 10−5 | 1.2 × 10−5 |
| BTRC | rs10883618 | A | G | 2.6 × 10−5 | 1.8 × 10−4 | 4.1 × 10−9 | 1.5 × 10−6 | 4.6 × 10−3 |
| LIN28A | rs4274112 | A | G | 2.8 × 10−5 | 2.5 × 10−28 | 8.5 × 10−4 | 6.8 × 10−4 | 3.3 × 10−4 |
| ZNF420 | rs62108897 | C | A | 6.3 × 10−5 | 7.7 × 10−19 | 4.7 × 10−3 | 7.1 × 10−4 | NS |
| JUND | rs10686842 | TAAA | T | 6.4 × 10−5 | 7.4 × 10−24 | 3.7 × 10−4 | 1.6 × 10−19 | NS |
| DIPK1A | rs12733767 | C | T | 6.8 × 10−5 | 9.4 × 10−14 | 9.0 × 10−5 | 3.2 × 10−3 | NS |
| IGF2BP3 | rs34776209 | C | T | 6.9 × 10−5 | 1.8 × 10−47 | 8.4 × 10−4 | NS | NS |
| XPO4 | rs7321635 | A | C | 9.0 × 10−5 | 2.6 × 10−11 | 4.5 × 10−4 | NS | NS |
| FHL2 | rs55680124 | C | T | 1.1 × 10−4 | 4.2 × 10−4 | 2.6 × 10−9 | 6.0 × 10−8 | 2.3 × 10−7 |
| VCAN | rs115912456 | G | A | 1.8 × 10−4 | 3.7 × 10−34 | 1.8 × 10−3 | 3.5 × 10−14 | NS |
| RBL2 | rs72801843 | A | T | 1.9 × 10−4 | 8.8 × 10−52 | 8.9 × 10−6 | NS | 4.5 × 10−5 |
| NPPC | rs73000823 | C | T | 2.3 × 10−4 | 1.7 × 10−15 | 3.7 × 10−4 | 1.4 × 10−5 | NS |
| MYO1C | rs9905106 | T | C | 3.5 × 10−4 | 7.5 × 10−14 | 3.9 × 10−3 | 4.4 × 10−5 | NS |
| CDKAL1 | rs745771286 | G | GA | 3.9 × 10−4 | 2.7 × 10−11 | 4.8 × 10−5 | 4.7 × 10−5 | NS |
| GIP | rs4794005 | A | G | 4.3 × 10−4 | 8.8 × 10−15 | 1.1 × 10−3 | 4.9 × 10−4 | 3.6 × 10−4 |
| NCL | rs10202701 | T | C | 4.3 × 10−4 | 3.1 × 10−33 | 2.0 × 10−3 | 2.3 × 10−5 | NS |
| SOCS5 | rs62136933 | A | G | 5.7 × 10−4 | 9.0 × 10−32 | 2.1 × 10−4 | 3.8 × 10−11 | NS |
| CAMKMT | rs11893991 | A | G | 6.0 × 10−4 | 2.3 × 10−9 | 2.4 × 10−3 | NS | NS |
| RIN3 | rs117068593 | T | C | 6.0 × 10−4 | 8.8 × 10−62 | 3.9 × 10−3 | 3.8 × 10−10 | NS |
| JMJD1C | rs7924036 | T | G | 8.9 × 10−4 | 1.2 × 10−5 | 1.2 × 10−13 | NS | NS |
| TRIB1 | rs4870941 | G | C | 1.3 × 10−3 | 1.1 × 10−39 | 2.1 × 10−3 | NS | NS |
| SDCCAG8 | rs2994330 | T | G | 2.4 × 10−3 | 6.6 × 10−12 | 9.6 × 10−5 | 3.0 × 10−4 | NS |
| NYAP2 | rs2054079 | T | C | 3.0 × 10−3 | 3.9 × 10−4 | 4.3 × 10−9 | NS | NS |
| MAML3 | rs57800857 | C | A | 3.5 × 10−3 | 4.0 × 10−7 | 6.4 × 10−11 | 1.4 × 10−13 | 2.7 × 10−4 |
| PITX1 | rs4976261 | G | C | 3.6 × 10−3 | 8.7 × 10−43 | 1.7 × 10−3 | NS | NS |
| PKDCC | rs3035165 | T | TTA | 3.7 × 10−3 | 6.9 × 10−14 | 1.0 × 10−3 | 3.0 × 10−8 | NS |
| HTT | rs362307 | C | T | 3.9 × 10−3 | 2.5 × 10−7 | 1.1 × 10−9 | 2.8 × 10−9 | 1.3 × 10−6 |
| ZNF462 | rs902144 | C | G | 4.0 × 10−3 | 7.2 × 10−13 | 4.0 × 10−4 | 1.7 × 10−3 | NS |
NS, not significant (p > 0.005). SNP, single nucleotide polymorphism. Handgrip strength: any type of handgrip strength (maximal or relative handgrip strength, left or right handgrip strength, handgrip strength in older adults) with the lowest p value. Protective allele: allele associated with greater strength, lean mass, and walking speed and low risk of obesity and T2D. Risk allele: allele associated with lower strength, lean mass, walking speed and high risk of obesity and T2D.