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. 2023 Jan 27;28(3):1260. doi: 10.3390/molecules28031260

Table 4.

Weighted scores for the eye irritation test of 5 FU-containing formulations.

Lesions in the Treated Eyes Individual Scores for Eye Irritation by
5 FU Gel Normal Saline (0.9% NaCl)
In Rabbit Number In Rabbit Number
1st 2nd 3rd 1st 2nd 3rd
Cornea
a. Opacity 1 0 0 0 0 0
b. Involved area of cornea 4 4 4 4 4 4
Total scores = (a × b × 5) = 20 0 0 0 0 0
Iris
a. Lesion values 1 0 0 0 0 0
Total scores = (a × 5) = 5 0 0 0 0 0
Conjunctiva
a. Redness 1 0 0 0 0 0
b. Chemosis 0 0 0 0 0 0
c. Mucoidal discharge 1 0 0 0 0 0
Total scores = (a + b + c) × 2 = 4 0 0 0 0 0
AMSN-CMC-FU gel Normal saline (0.9% NaCl)
Cornea
a. Opacity 0 0 1 0 0 0
b. Involved area of cornea 4 4 4 4 4 4
Total scores = (a × b × 5) = 0 0 20 0 0 0
Iris
a. Lesion values 0 0 0 0 0 0
Total scores = (a × 5) = 0 0 0 0 0 0
Conjunctiva
a. Redness 0 0 1 0 0 0
b. Chemosis 0 0 0 0 0 0
c. Mucoidal discharge 0 0 0 0 0 0
Total scores = (a + b + c) × 2 = 0 0 2 0 0 0
AMSN-FU gel Normal saline (0.9% NaCl)
Cornea
a. Opacity 0 1 0 0 0 0
b. Involved area of cornea 4 4 4 4 4 4
Total scores = (a × b × 5) = 0 20 0 0 0 0
Iris
a. Lesion values 0 0 0 0 0 0
Total scores = (a × 5) = 0 0 0 0 0 0
Conjunctiva
a. Redness 0 1 0 0 0 0
b. Chemosis 0 0 0 0 0 0
c. Mucoidal discharge 0 0 0 0 0 0
Total scores = (a + b + c) × 2 = 0 2 0 0 0 0