4CzBnBN |
(2,3,4,6)-3-Benzyl-2,4,5,6-tetra(9H-carbazol-9-yl)benzonitrile |
5-HT2A receptor |
5-Hydroxy-tryptamine 2A receptor |
AD |
Alzheimer’s disease |
ALS |
Amyotrophic lateral sclerosis |
Am
|
Molar activity |
AMPA receptor |
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor |
BEMP |
2-tert-butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine |
CB2 receptor |
Cannabinoid receptor type 2 |
CNS |
Central nervous system |
COX-1, -2 |
Cyclooxygenase-1, -2 |
CSF1 |
colony stimulating factor 1 |
CuTC |
Copper(I) thiophene-2-carboxylate |
DBAD |
Di-tert-butyl azodicarboxylate |
DBN |
1,5-Diazabicyclo [4.3.0]non-5-ene |
DBU |
1,8-diazabicyclo [5.4.0]undec-7-ene |
dc |
Decay-corrected |
DCC |
N,N′-Dicyclohexylcarbodiimide |
de |
Diastereomeric excess |
DMA |
Dimethylacetamide |
DMF |
Dimethylformamide |
DMSO |
Dimethyl sulfoxide |
DPSO |
Diphenyl sulfoxide |
d.r. |
Diastereomeric ratio |
dtbbpy |
4,4’-Di-tert-butyl-2,2’-bipyridine |
FIH |
First-in-human |
FMDS |
Fluoride-mediated desilylation |
HOSA |
Hydroxylamine-O-sulfonic acid |
HPLC |
High-performance liquid chromatography |
IPr |
1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene) |
K222
|
4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo [8.8.8]hexacosane |
MAO-B |
Monoamine oxidase B |
mGluR5 |
Metabotropic glutamate receptor 5 |
mHTT |
Mutant huntingtin protein |
NMDA |
N-methyl-D-aspartate |
NMP |
N-Methyl-2-pyrrolidone |
PD |
Parkinson’s disease |
PDE7 |
Phosphodiesterase 7 |
PET |
Positron emission tomography |
ppy |
2-Phenylpyridine |
prec |
precursor |
quant. |
quantitative |
RCC |
Radiochemical conversion |
RCP |
Radiochemical purity |
RCY |
Radiochemical yield |
Ref. |
Reference |
rt |
Room temperature |
t1/2
|
Half-life |
TBAT |
Tetrabutylammonium difluorotriphenylsilicate |
TBAI |
Tetra-n-butylammonium iodide |
TE |
Trapping efficiency |
THF |
Tetrahydrofuran |
TMEDA |
Tetramethylethylenediamine |
TMS |
Trimetylsilyl |
TrkB/C |
Tropomyosin receptor kinase B/C |
TSPO |
Translocator protein |