Figure 2.

Schematic illustration of the fabrication and application of TCP–TN–DOX scaffolds for therapy of osteosarcoma. F127 and TCP were mixed to obtain homogeneous printing glue for printing scaffolds using a 3D printing machine. The scaffolds were then sintered to obtain TCP scaffolds, which were immersed into solutions containing TiN and PDLLA, and solutions containing DOX and PDLLA to obtain TCP–TN–DOX scaffolds. The TCP–TN–DOX scaffolds were implanted into mice bearing osteosarcoma to achieve synergetic effects of photothermal therapy and chemotherapy (reproduced with permission from Reference [38], Copyright 2021, American Chemical Society).