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. 2023 Jan 29;13(3):551. doi: 10.3390/nano13030551

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic illustration of the process for preparing BGC-HM-DOX scaffold and its application for the combined photothermal therapy and chemotherapy of osteosarcoma. Hemin particles and DOX are integrated onto 3D-printed BGC scaffolds by using the polymer PDLLA as the medium. The BGC bulk scaffold can offer mechanical support for bone tissue after implantation into bone defects derived from surgical removal of osteosarcoma (reproduced with permission from Reference [39], Copyright 2021, Elsevier).