Table 3.
IC50 values of compounds 3, 5–7 and their sAuNP conjugates, as well as their mixtures (m) of bound and unbound AuNP conjugates, against MCF-7 cells.
| IC50 (μg/mL) | |||
|---|---|---|---|
| Compound | Compound Alone | AuNP-1 a | AuNP-2 b |
| Doxorubicin (3) | 17.9 | 15.9 | >50 |
| Tsitsikammamine A (6) | 11.1 | >50 c | >50 c |
| Tsitsikammamine B (7) | 9.9 | 16.0 | >50 c |
| 14-bromodiscorhabdin C (5) | 8.3 | 19.9 | >50 c |
a mixture of natural product and sAuNP. b mixture of natural product and sAuNP after removal of unbound natural products. c IC50 > maximum treatment dose used [50 μg/mL].