Table 2.
Nutritional and ponderal body weight characteristics of the cohort.
| Total (n = 38) |
Cholestasis Resolution | Infants with Gut Disease Cholestasis Resolution |
Infants without Gut Disease Cholestasis Resolution | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No (n = 10) |
Yes (n = 28) |
p | No (n = 5) |
Yes (n = 22) |
p | No (n = 5) |
Yes (n = 6) |
p | ||
| PN initiation (DOL) | 0 [0; 2] | 0 [0; 0] | 1 [0; 5] | 0.013 | 1 [1; 1] | 1 [1; 1] | 0.15 | 1 [1; 1] | 8 [1; 13] | 0.13 |
| Days with PN | 74 [48; 106] |
70 [44; 112] |
76 [51; 97] |
0.79 | 64 [59; 113] |
89 [70; 106] |
0.71 | 75 [39; 108] |
32 [22; 48] |
0.10 |
| Days on OVTM treatment | 39 [11; 52] |
19 [8.0; 50] |
40 [20; 55] |
0.41 | 22 [9; 41] |
46 [28; 74] |
0.17 | 15 [14; 93] |
16 [6; 23] |
0.36 |
| Sepsis with OVTM | 81.6% (31) | 60.0% (6) | 89.3% (25) | 0.06 | 100% (5) | 90.9% (20) | >0.99 | 20% (1) | 83.3% (5) | 0.08 |
| EN before OVTM (mL/kg/day) | 20.0 [15.0; 50.0] |
16.0 [8.0; 33.0] |
20.0 [15.5; 56.8] |
0.40 | 0.0 [0.0; 16] |
0.0 [0.0; 11.8] |
0.84 | 0.0 [0.0; 0.0] |
7.5 [0.0; 39.0] |
0.08 |
| EN after OVTM (mL/kg/day) | 90.0 [30.0; 110] |
0.0 [0.0; 0.0] |
92.5 [60.0; 110] |
0.10 | 0.0 [0.0; 0.0] |
77.5 [20.8; 100] |
0.002 | 0.0 [0.0; 0.0] |
105 [77.5; 110] |
0.004 |
| 1 EN >100 mL/kg/day | 61.1% (22) | 40.0% (4) | 69.2% (18) | 0.14 | 50% (2) | 65% (13) | 0.62 | 40% (2) | 83.3% (5) | 0.24 |
| DOL when EN >100 mL/kg/day was reached | 47 [30; 61] |
43 [28; 57] |
47 [30; 85] |
0.73 | 27 [25; 28] |
50 [40; 92] |
0.09 | 57 [56.5; 57.5] |
30 [19; 30] |
0.05 |
| Finish OVTM (DOL) | 64 [44; 100] |
60 [46; 101] |
67 [46; 96.0] |
0.80 | 63 [57; 93] |
71 [61; 107] |
0.55 | 56 [43; 133] |
35 [22; 46] | 0.10 |
| Final conjugated bilirubin (mg/dL) | 1.3 [0.7; 1.98] |
4.5 [4.1; 11.1] |
1.1 [0.58; 1.6] |
<0.001 | 4.2 [3.67; 7.92] |
0.97 [0.52; 1.30] |
0.002 | 10.4 [4.5; 11.1] |
1.58 [1.29; 1.67] |
0.006 |
| BWG (g/day) | 16.0 [11.2; 21.0] |
14.8 [12.2; 21.0] |
16.0 [10.3; 21.0] |
0.80 | 14.5 [12.0; 15.0] |
16.0 [11.8; 21] | 0.20 | 22.0 [13.0; 28.0] |
16.4 [9.6; 16.9] |
0.41 |
| WG with OVTM (g) | 70.2 [20.5; 154] |
31.0 [10.8; 133] |
79.2 [27.2; 155] |
0.34 | 22.0 [8.8; 66.3] |
105 [35.2; 165] |
0.11 | 40.0 [17.1; 173] |
42.2 [9.8; 79.2] |
0.47 |
| WG with SMOFlipidTM (g) | 67.0 [30.2; 139] |
56.9 [34.5; 102] |
71.5 [28.2; 156] |
0.95 | 68.0 [41.8; 114] |
79.5 [44.5; 177] |
0.90 | 47.8 [32.0; 66.0] |
28.5 [9.3; 94.5] |
0.47 |
Data show median and interquartile range [Q1; Q3] for quantitative variables and percentage and sample size (n) for qualitative variables. p-Values (p) were extracted by chi-squared test or Mann–Whitney U test among cholestasis resolution groups. PN: Parenteral nutrition; DOL: days of life; BWG: body weight gain; WG: weight gain; EN: enteral nutrition; OV: Omegaven, 1 from start of PN to the end of OVTM.