Table 1.
Natural compounds that synergistically enhance the effects of cancer chemotherapy and their mechanisms.
| Natural Products | Molecular Structure | Cancer | Combined Chemotherapy Drugs | Mechanism |
|---|---|---|---|---|
| Curcumin |
|
Gastric cancer | Paclitaxel, doxorubicin, melphalan, and prednisone | NF-κB |
| Multiple myeloma | ||||
| Gambogic acid |
|
Non-small cell lung cancer | Cisplatin | NF-κB |
| Solamargine |
|
Non-small cell lung cancer | Cisplatin | Hedgehog |
| Sulforaphane |
|
Non-small cell lung cancer | Gefitinib | Hedgehog |
| Hederagenin |
|
Lung cancer | Paclitaxel, cisplatin | LC3-I, LC3-II |
| Tagitinin C |
|
Colorectal carcinoma | Erastin | Nrf2/HO-1 |
| Ginkgetin |
|
Non-small cell lung cancer | Cisplatin | Nrf2/HO-1 |
| Narirutin |
|
Lung adenocarcinoma | Cisplatin | TMEM16A |