Table 3.
Use of Liposomes in Breast Cancer Delivery System [48,49] | ||||
---|---|---|---|---|
Name | Year Approved | Content within | Applications | Lipid Composition |
Doxil | 1995 | Doxorubicin | Ovarian, breast cancer, and Kaposi’s sarcoma | HSPC:Chol:PEG 2000-DSPE |
Myocet | 2000 | Doxorubicin | Metastatic breast cancer | EPC:Chol |
Lipo-dox | 2012 | Doxorubicin | Breast and ovarian cancer | DSPC:Chol:PEG 2000-DSPE |
HSPC = L-α-phosphatidylcholine, hydrogenated (Soy), Chol = Cholesterol, PEG 2000-DSPE = PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE, DSPC = Distearoylphosphatidylcholine, EPC = 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine.