Table 1.

Binding data of compounds 8−12 and reference compound PZ-1643 for 5-HT₆ and D₃ receptors.

Compd	R	Ki 5-HT6R [nM] a	%inh Binding to D3R @1μM b
PZ-1643		27 c	98% (7 nM) c
8		11	–
9		6	54%
10		84	–
11		17	25%
12		556	–

^a Mean K_i values based on at least three independent binding experiments (SEM ≤ 18%) performed in HEK293 cells with stable expression of human 5-HT₆R. ^b Percentage displacement values at 10⁻⁶ M; performed at Eurofins in CHO cells with stable expression of human D₃R. ^c Data taken from [26].