Table 3.

Advantages of nanobodies relevant to developing therapeutics.

1	Highly stable and able to bind antigens with nanomolar affinity
2	High target specificity and lower inherent toxicity
3	It can be humanized
4	Combine the advantage of conventional antibodies with essential features of small molecule drugs
5	Able to address therapeutic targets not easily recognized by conventional antibodies (e.g., the active site of enzyme)
6	Administrated by routes other than intravenous administration
7	Produced cost-effectively on a large scale
8	Extremely lower immunogenic potential
9	Ability to cross the human blood–brain barrier to reach targets in the brain