Table 1. Demographic characteristics and parameters of oxidative stress in all healthy subjects and MS patients and according to sex.
Quantitative variables are presented as mean ± Sd; * age of patients when was diagnosed the MS; TOS: total oxidative status; TAS: totalantioxidant status; OSI: oxidative stress index; 8-oxodG: 8-oxo-7,8-dihidro-2-deoxiguanosine; a differences between all participants in control group and MS group; b differences between control and MS in male population; c differences between control and MS in the group in female population; d differences between males and females in the MS group; e differences between males and females in the control group.
| Biomarker | All | Males | Females | |||
|---|---|---|---|---|---|---|
| Control group<br>(n=254) | MS patients<br>(n=175) | Control group<br>(n=81) | MS patients<br>(n=76) | Control group<br>(n=173) | MS patients<br>(n=99) | |
| Age (years)* | 36.90±8.78a | 33.43±9.10 | 37.41±7.82b | 33.22±8.05 | 36.62±9.21c | 33.60±9.93 |
| MS duration (years) | - | 7.56±5.60 | - | 7.81±4.72 | - | 7.41±8.72 |
| Males, n (%)<br>Females, n (%) | 81 (31.9)a<br>173 (68.1) | 76 (43.4)<br>99(56.6) | - | - | - | - |
| Non-smokers, n (%)<br>Former smokers, n (%)<br>Passive smokers, n (%)<br>Current Smokers, n (%) | 140 (55.1)<br>24 (9.4)a<br>6 (2.4)a<br>84 (33.1) | 77 (44.0)<br>4 (2.2)<br>40 (22.8)<br>56 (32.0) | 48 (59.2)<br>6 (7.4)<br>2 (2.5)b<br>25 (30.9) | 34 (44.8)<br>1 (1.3)<br>16 (21.0)<br>25 (32.9) | 92 (53.2)<br>18 (10.4)c<br>4 (2.3)a<br>59 (34.1) | 43 (43.4)<br>3 (3.1)<br>24 (24.2)<br>29 (29.3) |
| TAS<br>(mmol Trolox Equiv/L) | 2.02±0.21 | 2.00±0.20 | 2.18±0.18b,e | 2.09±0.21d | 1.94±0.18 | 1.93±0.17 |
| TOS<br>(μmol H2O2 Equiv/L) | 8.67±1.85a | 9.02±1.76 | 8.38±1.99 | 8.55±1.67d | 8.81±1.76c | 9.40±1.76 |
| OSI<br>(arbitrary units) | 0.43±0.10a | 0.45±0.10 | 0.39±0.10e | 0.41±0.09d | 0.45±0.09c | 0.49±0.10 |
| 8-oxodG/ creatinine<br>(nmol/mmol) | 1.18±0.56a | 1.58±1.09 | 1.31±0.49e | 1.44±0.72 | 1.12±0.58c | 1.70±1.31 |