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. 2023 Feb 11;21:117. doi: 10.1186/s12967-023-03953-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Subgroup analysis of the microbial compositions in different IBS subtypes. A: The vertical bar chart presenting the microbiota compositions among IBS with predominant constipation (IBS-C), predominant diarrhea (IBS-D) and healthy controls at the phylum level. B: Boxplots of the Shannon and Simpson index among the three groups. C. Horizontal Lollipop plots representing the median relative abundance of significantly enriched or depleted genera among the three groups. The background colors represent the different phyla they belong to. Kruskal-Wallis Test was performed and *, **, *** stands for p-value < 0.01, 0.005 and 0.001, respectively)