Fig. 6.

DOX influences AKT activation and promotes EMT progression in HR+HER2− BC cells. A and B p-AKT, AKT and GAPDH protein levels were examined by western blot in DOX-treated and control HR+HER2− BC cells after 24 h. C p-AKT, AKT, METTL3 and GAPDH protein levels were examined by western blot in in NC and knockdown METTL3 groups of HR+/HER2− BC cells. D p-AKT, AKT, METTL3 and GAPDH protein levels in the NC, NC-DOX, METTL3 overexpression and METTL3 overexpression -DOX groups were examined by western blotting. E E-cadherin, N-cadherin, p-AKT, AKT, METTL3 and GAPDH protein levels in the shNC, shNC-LY294002, shMETTL3 and shMETTL3-LY294002 groups were examined by western blotting. F p-AKT, AKT, METTL3, CDKN1A and GAPDH protein levels in the NC, shMETTL3 and shMETTL3-CDKN1A groups were examined by western blotting